"Jamming in Biological Tissues" by Lisa Manning (Syracuse University)

Date: 
Thursday, May 26, 2016 - 4:00am to 5:00pm
Series: 
Physics and Astronomy Colloquium

Thursdays, 4:00-5:00 pm

1-434 Physics and Astronomy (map)
Reception from 3:30-4:00 p.m.
(unless otherwise posted)

 

Guest Speaker: Lisa Manning (Syracuse University)

Talk Title:  “Jamming in Biological Tissues”

Abstract:

Biological tissues involved in important processes such as embryonic development, lung function, wound healing, and cancer progression have recently been shown to be close to a liquid-to-solid or "jamming" transition, similar to the one that occurs when oil and water are mixed to make mayonnaise. In mayonnaise and materials like it, a disordered liquid-to-solid transition occurs when the packing density of oil droplets increases past a critical threshold, and over the past 20 years physicists have made great progress in understanding the universal nature of this transition. However, existing theories cannot explain observations of jamming transitions in confluent biological tissues, where there are no gaps between cells and the packing density is always unity. I will discuss a new theoretical framework for predicting rates of cell migration in biological tissues, and show that this model predicts a novel type of critical rigidity transition, which takes place at constant packing density and depends only on single cell properties such as the number of adhesion molecules expressed. I will show that our a priori theoretical predictions with no fit parameters are precisely realized in cell cultures from human patients with asthma, and discuss how these ideas might also be applied to understand other processes in embryonic development and cancer progression.

 

For more information, contact Jay Hauser

We thank the following people for their contributions to the wine fund for the post-colloquium reception:
Prof. Dolores Bozovic, Prof. Mike Cornwall, Prof. Bob Cousins, Prof. Andrea Ghez, Prof. Karoly Holczer, Prof. Eric Hudson, Robert Huff, Prof. Alex Kusenko, Prof. Myank Mehta, Prof. John Miao, Prof. Roberto Peccei, Prof. Claudio Pellegrini, Prof. David Saltzberg, Prof. Jean Turner and Prof. Ben Zuckerman.

Event Attachments: 
Location: 
1-434 PAB