Dolores Bozovic

Dolores Bozovic
Professor
Soft Condensed Matter

Office: 3-112 Knudsen
Phone: (310) 825-6176
E-Mail: [javascript protected email address]
Website

Educational Background: 
  • Ph.D. in Physics, Harvard University, 2001
  • B.A. in Physics, Stanford University, 1995
Positions Held: 
  • 2011-present: Associate Professor, Department of Physics and Astronomy, University of California, Los Angeles, CA
  • 2005-2011: Assistant Professor, Department of Physics and Astronomy, University of California, Los Angeles, CA
  • 2001-2005: Postdoctoral Associate, Howard Hughes Medical Institute, Rockefeller University, New York, NY
Research Interest: 

My current research interests fall at the interface between physics and sensory neuroscience, and focuses at understanding the basic processes of hearing. The first step in our processing of sound is mediated by hair cells, specialized cells of the inner ear that detect mechanical stimuli and transduce them into electrical signals that are passed on to the rest of the brain. These cells display remarkable properties; they can detect displacements smaller than 1 nm, and yet can withstand loud sounds, covering a range of about 6 orders of magnitude. Further, they can amplify incoming stimuli and sustain prolonged oscillations, despite being immersed in a dissipative fluid environment. The mechanisms behind hair cell activity are still not fully elucidated, making hearing one of the least understood senses. Research in this laboratory is aimed at addressing some of these long-open questions.

Selected Publications: 
 
  • "Mechanical amplification exhibited by quiescent saccular hair bundles," Y. Roongthumskul and D. Bozovic, Biophys. J., in press (2015).
  • "Phase-locked spiking of inner ear hair cells and the Driven Noisy Adler Equation," R. Shlomovitz, Y. Roongthumskul, S. Ji, D. Bozovic, and R. Bruinsma, Interface Focus, 4, 2014022 (2014).
  • "Cubic magnetic nanoparticles for ultrafast mechanical control of inner ear hair cells," J. Lee, J. Kim, M. Levy, A. Kao, S. Noh, D. Bozovic, and J. Cheon, ACS Nano, 8, 6590 (2014).
  • "Low-frequency entrainment of bursts in oscillatory hair cells," R. Shlomovitz, L. M. Fredrickson-Hemsing, A. Kao, S. W. F. Meenderink, R. Bruinsma, and D. Bozovic, Biophys. J., 104, 1661 (2013).
  • "Phase slips in oscillatory hair bundles," Y. Roongthumskul, R. Shlomovitz, R. Bruinsma, and D. Bozovic, Phys. Rev. Lett., 110, 148103 (2013).
  • "Mechanical overstimulation of hair bundles: suppression and recovery of active motility," A. Kao, S. W. F. Meenderink, and D. Bozovic, PLOS One, 8, e58143 (2013).
  • "Mode-locked dynamics of hair cells of the inner ear," L. M. Fredrickson-Hemsing, S. Ji, R. Bruinsma, and D. Bozovic, Phys. Rev. E, 86, 21915 (2012). 
  • "Coupling and elastic loading affect the active response by the inner ear hair cell bundles," C. E. Strimbu, L. M. Fredrickson-Hemsing, and D. Bozovic, PLOS One, 7, e33862 (2012).
  • "Dynamics of freely oscillating and coupled hair cell bundles under mechanical deflection," L. M. Fredrickson-Hemsing, C. E. Strimbu, Y. Roongthumskul, and D. Bozovic, Biophys. J., 102, 1785-1792 (2012).
  • "Magnetic actuation of hair cells," D. Rowland, Y. Roongthumskul, J. H. Lee, J. Cheon, and D. Bozovic, App. Phys. Lett., 99, 193701 (2011).
  • "Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundles," Y. Roongthumskul, L. Fredrickson-Hemsing, A. Kao, and D. Bozovic, Biophys. J., 101, 603 (2011). 
  • "Effects of the somatic ion channels upon spontaneous mechanical oscillations in hair bundles of the inner ear," D. Ramunno-Johnson, A. Kao, C. E. Strimbu, L. M. Fredrickson-Hemsing, and D. Bozovic, Hear. Res., 268, 163 (2010). 
  • "Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculus," C. E. Strimbu, A. Kao, J. Tokuda, D. Ramunno-Johnson, and D. Bozovic, Hear. Res., 265, 38 (2010).
  • "Correlated movement of air bundles coupled to the otolithic membrane in the bullfrog sacculus," C. E. Strimbu, D. Ramunno-Johnson, L. Fredrickson, K. Arisaka, and D. Bozovic, Hear. Res., 256, 58 (2009).
  • "Distribution of frequencies of spontaneous oscillations in hair cells of the bullfrog sacculus," D. Ramunno-Johnson, C. E. Strimbu, L. Fredrickson, K. Arisaka, and D. Bozovic, Biophys. J., 96, 1159 (2009).